Posters :: Genapha (Daley D, Zamar D, Park J, Tripp B)

If you submit a poster to the conference and would like to be included here, please contact the co-chairs with your poster details.

The following are confirmed poster presentations. Note that there is no dedicated poster session for the workshop – there is just one general poster session for the conference. The information below should help you to find the posters relevant to our workshop.

Lab2: a Web platform for mouse geneticists
Paul LF Tang, You-Qiang Song
Department of Biochemistry, The University of Hong Kong, Hong Kong, China

Communicating Results from International Collaborations in the Information Age: Introducing the Genomic Applications for Humanity (Genapha) Website

Denise Daley, D Zamar, J Park, B Tripp
James Hogg iCAPTURE Center, University of British Columbia, Vancouver, BC

In order for research to have impact it must first be successfully communicated. In an era of high throughput genome wide association and candidate gene studies how do we translate the results from international genomic consortiums effectively? Only a small number of results are published, generally only statistically significant observations, leaving the vast majority of results undisclosed.  To facilitate meta-analyses and the identification of genes with smaller effect sizes (OR <1.4) we are releasing association results for 98 candidate genes from our study that includes 5,565 individuals recruited into four studies from Canada and Australia.  One way to communicate findings is to utilize the World Wide Web and we present Genapha (www.genpaha.ca) as a model for knowledge translation from high throughput genomic platforms. Genapha is an online database of results, providing rapid, full, and open disclosure of our research findings to the scientific community.

The database has been interfaced with other databases such as dbSNPs, OMIM, PubMed, The Genetic Association Database, Innate Immunity, HapMap, Seattle SNPs, PharmGKB, UCSC Genome Browser, and KEGG databases. Interfaces and search tools allow users to rapidly filter information and identify genes, single nucleotide polymorphisms (SNPs), and association results most pertinent to their own research, not just from our study, but the body of knowledge that is available in the electronic databases interrogated by Genapha. We have implemented novel graphical user interfaces to allow visitors to build custom graphs and plots of interest to them using our results database.  Detailed descriptions of the study designs, populations, and allele frequencies along with tutorials are hosted on the website.

An interface with the KEGG pathway database (http://www.genome.ad.jp/kegg/pathway.html) allows users to view association results for genes and SNPs in the context of larger genetic pathways. Analytical tools for pathway analysis using the genotype information from the four studies are in development.

We are in the process of indexing, cataloging, and extracting information from all genetic association studies for the traits of asthma, atopy, airway-hyper-responsiveness, and atopic asthma.  This information will be complied into the AsthmaGen database.  Meta-analysis is planned and the results will be available on the AsthmaGen database/website.   Results from the meta-analysis, SNP function, and pathway information can be used in statistical modeling.

Open Data and Apache CouchDB
Paul J Davis, S Kumar
New England Biolabs

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